Nov 9, 2024 • 10:42 ET • 4 min read Picks made at time of writing may not reflect live odds. My analysis The Missouri Tigers had their two-game win streak shattered with a 34-0 drubbing at the hands of then-15th-ranked Alabama. Not only did they get smacked around, but quarterback Brady Cook left for the second straight game with an injury and remains a question mark for this game. If he can’t play, former Notre Dame pivot Dew Pyne will get the start. He didn’t exactly rally the troops against the Crimson Tide, going 6-for-12 for 42 yards and three interceptions. It’s likely the Oklahoma Sooners will try to force Pyne to beat them with the pass, as OU’s run defense is 17th-best in the nation, holding teams to 106.1 yards per game. Meanwhile, Jackson Arnold is on an upward trajectory after getting renamed the starter. He was solid in a 59-14 obliteration of Maine, going 15-for-21 for 224 yards and two TDs, helping OU bust out of a three-game losing skid. Arnold now has four TD tosses and no interceptions in the last two games while completing passes at better than a 70% rate. If OU can welcome back pass catchers Jalil Farooq and Deion Burks from injury, that could really help its quarterback find a rhythm. Mizzou is not to be taken lightly on defense, though, as it holds opponents to under 300 yards of offense per game and boasts a Top-10 passing defense in college football, allowing just 164.8 yards per game.